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Hello stranger, are you sick enough for me?

June 25, 2007

AUSTRALIAN lonely hearts with health conditions such as cancer, herpes, irritable bowel syndrome and allergies are turning to a specialised online dating service in their quest to find love.

The website Prescription4Love is the brainchild of American Ricky Durham, 46, who was inspired by his late brother Keith’s struggle to meet new people while he suffered from Crohn’s disease. Keith died in 2004.

“It was hard for him to disclose his disease to anyone, but it was really hard for him to tell someone he had a colostomy bag,” Mr Durham said.

“When do you tell someone that you have a colostomy bag? The first time you meet? The first date? The second? So I thought if he met someone at a website where everyone had the same condition, there would be nothing to disclose.”

The free site is one of a growing number of dating and friendship services specialising in health conditions, with sexually transmitted infections now leading the way.

US-based websites such as Positive Singles and Antopia, a herpes group claim to have tens of thousands of infected members and boast hundreds of “success stories”.

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Mr Durham, from Atlanta, Georgia, said he began Prescription4Love for sufferers of 11 conditions, including cancer, obesity, deafness, herpes, HIV, diabetes, Crohn’s disease and allergies. At the request of clients, he has recently expanded the site to include those with less common conditions such as epilepsy, paraplegia and human papillomavirus, which causes genital warts and cervical cancer, as well as transplant patients and burns victims.

The site has about 1000 members mostly in the US, but Mr Durham said people from Australia, Canada, Britain and Israel had also joined up.

Clients include “Sweet Lady”, 24, from Oklahoma, who’s deaf and “looking for a date or making friends” and Kelvin, 45, from Pennsylvania, a recovering alcoholic with diabetes “looking for love”.

Mr Durham, who had no previous experience in IT said honesty was important in a relationship, but finding an opportune time and situation to raise such subjects as medical conditions, particularly embarrassing ones, could be difficult.

“By using Prescription4Love.com, you can be honest in advance,” he said.

Lija Jarvis from mainstream Australian online dating website RSVP said that, while it doesn’t have any services catering for disabled people, this has been identified as a potential need.

She said the feature might be built into sub sites in the future.

RSVP is owned by Fairfax Media, publisher of smh.com.au and theage.com.au.

Posted by toshko under Herpes News | Comments (0)

Herpes No. 1 Virus Impacting, Killing Corals

June 21, 2007

Only, for corals, a herpes virus infection isn’t just annoying.

It can be lethal, and it and other diseases are possibly a big factor in the deaths of coral reefs that humans are causing throughout the world’s oceans, new research shows.

Scientists have known for years that humans are killing corals indirectly and directly through global warming, overfishing and pollution.

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Many reefs off populous coasts have been decimated, while those near uninhabited areas are often thriving.

“For some reason, when you put people next to reefs, they die,” said microbiologist Forest Rohwer of San Diego State University at a recent symposium at the American Museum of Natural History here.

A 2004 study found that 70 percent of the world’s reefs had been destroyed or were threatened by global warming and other human activities.

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Herpes Virus Hijacks DNA Repair Process

June 14, 2007

The DNA damage response normally fixes DNA errors caused by radiation or other environmental factors, or mistakes accidentally introduced when cells copy their genetic material prior to dividing.

In the murine (or mouse-infecting) herpes virus they studied, researchers at Washington University School of Medicine in St. Louis identified a protein that can trick the mouse cell into turning on the DNA damage response. They also showed that Epstein-Barr virus, a human herpes virus, has a similar protein. Scientists found that blocking murine herpes virus from activating the DNA damage response caused viral replication rates to plummet.

“We don’t want to treat viral infection by blocking DNA damage response systemically because this process is used constantly throughout the body and is very important to preventing cancer,” says lead author Vera Tarakanova, Ph.D., a postdoctoral fellow. “However, by targeting the viral protein responsible for activating the DNA damage response, we may be able to block viral replication. In addition, determining how the DNA repair response helps viral replication may enable us to develop novel strategies to treat infection.”

The paper appears online this week in Cell Host & Microbe. Scientists have known for some time that viral infection of cells activates the DNA damage response. But researchers had assumed that this activation occurred because repair mechanisms were mistaking replicating viral DNA for damaged or dysfunctional cellular DNA.

“Viruses sometimes structure their own DNA differently than cellular DNA,” Tarakanova notes. “Many of us thought that such differences might be triggering the DNA damage response.” Working in the laboratory of Herbert W. “Skip” Virgin, M.D., Ph.D., Edward Mallinckrodt Professor and head of the Department of Pathology and Immunology, Tarakanova found that murine herpes virus, rather than the host cell, was triggering the DNA damage response. She showed that introducing just one viral protein into cells led to activation of two cellular proteins involved in the damage response, ATM and H2AX.

The viral protein that triggered this inappropriate activation, orf36, is a kinase, a type of protein that chemically modifies other molecules to activate different processes or transmit signals. Genetic comparisons with several human herpes viruses revealed kinases similar to orf36 in the human viruses. Scientists then took a similar kinase from human Epstein-Barr virus and showed that introducing it into cells also activated the DNA damage response.

When the research team genetically disabled orf36 in the murine herpes virus and infected mouse cells with it, the virus no longer activated the DNA damage response. The virus’s ability to replicate also dramatically decreased.

Kinases are versatile proteins that sometimes play multiple roles. To ensure that enhanced viral replication wasn’t linked to orf36’s interactions with other molecules, researchers turned to mice lacking the genes for ATM and H2AX, the damage response proteins activated by infection. When they infected cells from these mice with murine herpes virus, its ability to reproduce was again curtailed. How DNA damage response benefits viral replication is still a mystery and a topic of continuing investigation in the Virgin lab.

“The discovery that induction of the cells’ DNA damage response is an intentional viral strategy, rather than a passive cellular response to viral invasion, means that we should look into whether other DNA viruses use a similar approach to enhance their growth,” says Virgin.

Reference: Tarakanova VL, Leung-Pineda V, Hwang S, Yang C-W, Matatall K, Basson M, Sun R, Piwnica-Worms H, Sleckman BP, Virgin HW IV. Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host and Microbe, online edition.

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Manson Amongst Prisoners Released With Herpes

June 13, 2007

Corcoran State Prison, CA –Convicted mass-murderer Charles Manson has today been released from Corcoran State Prison for medical reasons, but will be confined to his home with an electronic ankle bracelet for 48 years.

Reggie Dunbar, spokesperson from the prison, said that the California District Attorney’s office granted Manson’s release shortly after it was informed he had had a herpes rash that looked like a “swastika” on his forehead.

“Poor Charlie, he was really embarrassed, I can’t imagine the emotional scars this has left him with,” Dunbar added.

The release of Manson has followed a mass exodus of prisoners from California prisons in what has been called, “The Herpes Defense.”

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Dunbar stated, “Once prisoners found out that a case of Herpes could get them them transferred to a home detention, the California prison population had a herpes outbreak that would rival USC’s Fraternity Row, both of which came from the same source.”

According to Dr. Reggie Athansoulis for the Center of Disease Control, herpes traditionally effects one in eight Americans, or basically everyone in California.

“It’s not life threatening, “Athansoulis said, “but it certainly threatened the show, ‘The Simple Life,’ where it originated.”

The Herpes Defense has now become a part popular culture, with reports of it being used in every day life. Reggie Stanthorpe, from Media watchdog group, Media Connection UK recently said, “Herpes is like a modern day Moses, leading prisoners out of prison, getting people out of traffic fines, excusing kids for late assignments. It’s no longer acceptable to blame traffic or ‘the baby’ for running late for social functions, but it’s perfectly acceptable now to blame herpes.”

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Herpes awareness campaign kicks off

June 6, 2007

Saying African-Americans face a disproportionally high incidence of genital herpes, a major drug maker and several health groups will launch a public awareness campaign today in Detroit.

Local radio and print ads are designed to educate people about the sexually transmitted disease, which can cause painful blisters and is not curable. The sponsors, led by Glaxo-SmithKline, will roll out future campaigns in Atlanta and Baltimore.

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“Herpes has always been one of those STDs that can be treated but never goes away,” said Dr. Peter Gulick, an East Lansing doctor and associate professor at Michigan State University. “You can get a reactivation years later, even if you don’t have sexual activity.”

About 40 percent of black adults in the United States have genital herpes — compared with 14 percent of whites and 12 percent of Mexican-Americans, according to an August 2006 study by the Centers for Disease Control and Prevention.

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All you need to know to give your smile the white stuff

June 5, 2007

A toothache can lead to headaches, loss of appetite and a bad attitude.

Chapped lips aren’t only uncomfortable, but unattractive.

And a canker sore is about as pleasant as an enema.

If our mouths aren’t feeling well, we’re not feeling well.

“The mouth, teeth, lip and gums are important for maintaining health, and they are also markers of overall health,” said University of California, Irvine Medical Center’s Dr. William B. Armstrong, who specializes in head and neck cancer surgery. “If someone is malnourished, the gums and teeth will show it. Poor oral care goes along with chronic disease.”

The mouth and lips are also key to an attractive appearance.

“Everyone always remembers someone’s smile,” said Anastazia Grey Woodin, a makeup artist and esthetician at Baker Street West Salon in Costa Mesa, Calif.

Filling-free and healthy

Eat a balanced diet, following the five major food groups (breads/grains; fruit; vegetables; dairy; meats/fish) to ensure you are getting all the nutrients your body needs to build and maintain strong bones, decay-resistant teeth and healthy gums, Dr. Nick Salvati, who owns a private dental practice in San Clemente, Calif., said.

Visit your dentist at least twice a year, said Salvati. And don’t forget to brush your teeth two to three times a day and floss.

Inspect your teeth and mouth for changes in gum color, bleeding areas, sores, or cuts on the gums or tongue whenever you brush, said Dr. Maged Zakhary, president of TruDental in Newport Beach, Calif.

Use an American Dental Association-approved fluoride toothpaste like Colgate Total, Biotene (for dry mouth) or Sensodyne (for sensitive teeth), Salvati said. Be careful about using whitening and tartar-control toothpastes since their additives can make teeth very sensitive. Though both types of toothpaste are safe for the most part, peroxide in whitening products and phosphate in tartar-control toothpastes can lead to sensitivity to temperature and peeling of mouth tissues.

Drink more water and cut down on soda, said dentist Dr. Pooneh Sabo, owner of OC Dental Center in Santa Ana, Calif. When you do drink soda, use a straw so the liquid stays in your mouth less. Dilute juices with water.

Watch your milk intake, Sabo said. Milk has a lot of sugar in it, so brush or rinse after drinking.

Gorgeous lips, nice smile

Avoid drawing too much past your lip line when applying color; overdraw only to correct the shape of your lips, Woodin said. When applying color, start your liner or lip brush at the side of your top lip and move upward.

Apply a few drops of peppermint or tea tree oil to your tongue or toothbrush to help freshen your breath and kill bacteria, UC Irvine dermatologist Dr. Christopher B. Zakhary said.

To keep your lips soft and supple, use lip balms that contain soothing, moisturizing ingredients like cocoa or shea butter, aloe vera, maple (an antioxidant), tea tree and/or vitamin E, said Tamara Freedman, esthetician and director of education at Spa Gregorie’s in Newport Beach, Calif.

Avoid ingredients like camphor and menthols because they will dry out your lips, causing you to use more and more product. Don’t forget to get a lip balm with sun protection, said Zachary.

For fuller lips, consider hyaluronic acid fillers like Restylane and Juvederm, Zachary said. Fillers generally last three to nine months, though some companies are making ones that last a few years.

Use glycolic acid products around the lips twice a day to exfoliate the area and make the skin look smoother, said Dr. Valdemar Ascencio, a plastic surgeon at Saddleback Memorial Medical Center in Laguna Hills, Calif.

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ORAL FRUSTRATIONS

Orange County, Calif.-area dentists Dr. Nick Salvati and Dr. Pooneh Sabo, and head/neck cancer surgery specialist Dr. William B. Armstrong offer their insight on a few common mouth conditions.

Canker sores: A recurring problem for 20 to 50 percent of the population, canker sores may be caused by a bacterium that lays dormant in the salivary glands, but releases toxins during times of mental and physical stress, trauma to the mouth, menstruation, etc., Salvati said. The result is a painful ulcer often the size of a dime on the soft mucosa (cheeks, inner lip, floor of the mouth, side of the tongue) inside the mouth.

Certain spicy foods can irritate an existing ulcer as well as cause a new one to form. While canker sores typically heal on their own, you can try using over-the-counter numbing treatments like Anbesol or prescription medications that can reduce pain and healing time.

Prevention tips include reducing stress and chances for oral trauma (for instance, limit gum chewing to prevent accidental cheek biting). Vitamin supplements like lysine may also help.

Cold sores: Cold sores, or fever blisters, are a recurring problem for about 40 percent of the population, Salvati said. They’re caused by the Herpes Simplex Virus (HSV), which is believed to be transmitted through respiratory secretions like coughing and sneezing, sexual or physical contact, and through the placenta at birth.

Cold sores typically appear as single or small groups of painful blisters on the roof of the mouth, gums, lips and nose. They can recur on a regular basis or randomly.

Treatment options include prescription antiviral medications and laser therapies. To prevent them, avoid eating or drinking from other people’s utensils or cups. Also, avoid touching the sore so you don’t spread it to other people or to other areas of your body, like your eyes.

Oral cancer: Cancer in the oral cavity can look like a white or red lesion, Armstrong said. It is often painless, but can also be painful and may bleed. You may think you bit your lip or tongue, but it doesn’t heal within a week or two.

Risk factors for developing oral cancer include cigarettes, chewing tobacco and alcohol. Treatment options depend on the extent of the tumor, and include surgery or radiation therapy.

Gum disease: Occurring in about 80 percent of Americans, gum disease is an inflammation of the gums, Sabo said. Since there’s often no pain associated with gum disease, many people have it without knowing it.

Symptoms can include red and inflamed bleeding gums, and foul odor in the mouth. In more advanced cases, teeth can become loose. Gum disease is caused by plaque and bacteria building up under the gums.

Treatment options include basic dental cleaning, deep cleaning, bone grafts to stabilize loose teeth and/or gum grafts.

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